Convenient Procedure for the Indium-Mediated Hydroxymethylation of Active Bromo Compounds: Transformation of Ketones into α-Hydroxymethyl Nitroalkanes
RG Soengas, AM Estévez
Index: Soengas, Raquel G.; Estevez, Amalia M. Synlett, 2010 , # 17 p. 2625 - 2627
Full Text: HTML
Citation Number: 3
Abstract
Abstract A very simple, safe and powerful method for the hydroxymethylation of 2- bromoesters and lactones under anhydrous conditions that avoids the use of gaseous formaldehyde is described. Moreover, under these conditions, bromonitroalkanes were converted into the corresponding α-monohydroxymethylated nitroalkanes, which are precursors of the corresponding α-amino acids. Considering the easy transformation of ...
Related Articles:
Total synthesis of papulacandin D
[Gioeli, Carlo; Balgobin, Neil; Josephson, Staffan; Chattopahyaya, Jyoti B. Tetrahedron Letters, 1981 , vol. 22, p. 969 - 972]
Solvent free tetrahydropyranylation of phenols and alcohols over zeolites HSZ as reusable catalysts
[Tetrahedron Letters, , vol. 38, # 23 p. 4169 - 4172]
[Journal of the American Chemical Society, , vol. 117, # 36 p. 9206 - 9212]
[Journal of the American Chemical Society, , vol. 117, # 36 p. 9206 - 9212]
[Journal of the American Chemical Society, , vol. 117, # 36 p. 9206 - 9212]