Tetrahedron

Synthesis of N-substituted benzo [c][1, 7]-and benzo [c][1, 8] phenanthrolin-(5H)-6-ones through a Pd-mediated Suzuki–Miyaura heteroaryl-aryl coupling reaction

C Genes, S Michel, F Tillequin, FH Poree

Index: Genes, Constance; Michel, Sylvie; Tillequin, Francois; Poree, Francois-Hugues Tetrahedron, 2009 , vol. 65, # 48 p. 10009 - 10015

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Citation Number: 6

Abstract

In the course of the search for non-camptothecin topoisomerase I inhibitors we have undertaken the synthesis of N-substituted benzo [c][1, 7]-and benzo [c][1, 8] phenanthrolinone derivatives. An intermolecular Suzuki–Miyaura heteroaryl-aryl coupling reaction was planned as the key step. Then a nitro reduction followed by a concomitant lactamization achieved the construction of the tetracycle structures. This methodology ...