The Synthesis of Thyromimetic Substances and Potential Inhibitors of Thyroxine1

CM Buess, T Giudici, N Kharasch, W King…

Index: Buess,C.M. et al. Journal of Medicinal Chemistry, 1965 , vol. 8, p. 469 - 474

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Citation Number: 13

Abstract

In a previous the basis for our approach to the synthesis of thyroxine analogs and potential inhibitors of thyroxine was summarized. The syntheses of eight novel analogs, Ia-d, IIa-c, and I11 are now reported; the synthetic scheme for Id was briefly communicated previously. 3 In view of current theories of thyroxine action and results of testing, the choice of compounds was made on the basis of the postulated relation between activity and ...