Zinc??Catalyzed Dehydrogenative N??Silylation of Indoles with Hydrosilanes

T Tsuchimoto, Y Iketani…

Index: Tsuchimoto, Teruhisa; Iketani, Yoshihiko; Sekine, Masaru Chemistry - A European Journal, 2012 , vol. 18, # 31 p. 9500 - 9504

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Citation Number: 19

Abstract

Due to their importance as nitrogen-protected indoles, N-silylindoles are recognized as indispensable synthetic platforms that can be used to construct valuable indole-based organic molecules.[1] N-Silylation of indoles is generally performed by a two-step sequence consisting of N-metalation of indoles with strong metallic bases (met–base), such as LiBu, KNACHTUNGTRENNUNG (SiMe3) 2, or NaH, and then treatment of the resulting N-metal ...