Non-peptidic small molecule inhibitors of XIAP

CM Park, C Sun, ET Olejniczak, AE Wilson…

Index: Bioorganic and Medicinal Chemistry Letters, , vol. 15, # 3 p. 771 - 775

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Citation Number: 66

Abstract

... Bioorganic & Medicinal Chemistry Letters. ... The resulting compounds were initially assayed by NMR, which is able to confirm binding to the SMAC binding site by the observation of chemical shift pertubations and to quantitate weak binding in the millimolar to micromolar range. ...