Bioorganic & medicinal chemistry

Polycyclic aromatic compounds as anticancer agents: structure–activity relationships of chrysene and pyrene derivatives

BK Banik, FF Becker

Index: Banik, Bimal K; Becker, Frederick F Bioorganic and Medicinal Chemistry, 2001 , vol. 9, # 3 p. 593 - 605

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Citation Number: 51

Abstract

A large number of diamides and diamines were synthesized using 6-amino chrysene and 1- amino pyrene as starting materials. A structure–activity study with cis-platinum as internal control against animal and human tumor lines was carried out in vitro. This study indicated that the in vitro cytotoxicity toward these lines depends on the functionality present in the molecules. The diamino compounds were found to be more potent than the diamides, and ...

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