Synthesis and characterization of degradable multivalent cationic lipids with disulfide-bond spacers for gene delivery

…, C Leal, RN Majzoub, NF Bouxsein, CR Safinya

Index: Shirazi, Rahau S.; Ewert, Kai K.; Leal, Cecilia; Majzoub, Ramsey N.; Bouxsein, Nathan F.; Safinya, Cyrus R. Biochimica et Biophysica Acta - Biomembranes, 2011 , vol. 1808, # 9 p. 2156 - 2166

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Citation Number: 40

Abstract

Abstract Gene therapy provides powerful new approaches to curing a large variety of diseases, which are being explored in ongoing worldwide clinical trials. To overcome the limitations of viral gene delivery systems, synthetic nonviral vectors such as cationic liposomes (CLs) are desirable. However, improvements of their efficiency at reduced toxicity and a better understanding of their mechanism of action are required. We present the ...