Synthesis of water-soluble paclitaxel derivatives by enzymatic acylation

YL Khmelnitsky, C Budde, JM Arnold…

Index: Khmelnitsky; Budde; Arnold; Usyatinsky; Clark; Dordick Journal of the American Chemical Society, 1997 , vol. 119, # 47 p. 11554 - 11555

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Citation Number: 107

Abstract

Paclitaxel, 1 a diterpenoid originally isolated from the bark of the Pacific yew, Taxus breVifolia, is a powerful antimitotic agent2 that acts by promoting tubulin assembly into stable aggregated structures. Although paclitaxel has shown tremendous potential as an anticancer compound, 3 its use as an anticancer drug is compromised by its poor aqueous solubility. For this reason, a number of water-soluble paclitaxel prodrugs have been ...