Tetrahedron letters

Synthesis of cyclic and acyclic Nα-methyl-Nω-alkyl-l-arginine analogues

KP Kokko, HB Hooper, TA Dix

Index: Kokko, Kyle P.; Hooper, H. Brooks; Dix, Thomas A. Tetrahedron Letters, 2004 , vol. 45, # 10 p. 2151 - 2153

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Citation Number: 6

Abstract

A series of Nα-methyl-alkyl-l-arginine (Arg) analogues have been synthesized from inexpensive, commercially available starting materials. These analogues, once incorporated into pharmaceutically relevant peptides, are expected to increase binding affinity, receptor selectivity, lipophilicity, and stability as demonstrated with analogues of similar design and structure.