Discovery of bioavailable 4, 4-disubstituted piperidines as potent ligands of the chemokine receptor 5 and inhibitors of the human immunodeficiency virus-1

WM Kazmierski, C Aquino, BA Chauder…

Index: Journal of Medicinal Chemistry, , vol. 51, # 20 p. 6538 - 6546

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Citation Number: 29

Abstract

... Journal of Medicinal ... Recent medicinal chemistry efforts have resulted in the discovery of several CCR5 antagonists currently in the clinic(1, 2) and ... Monomers were also selected from the BCUT chemistry space such that the distances between the resultant products and known ...