The first stereospecific synthesis of (+)-(1r, 2s, 4r)-4-amino-2-hydroxy-1-cyclopentanemethanol and (+)-carbocyclic thymidine.

L Ötvös, J Beres, G Sagi, I Tömösközi, L Gruber

Index: Otvos; Beres; Sagi; Tomoskozi; Gruber Tetrahedron Letters, 1987 , vol. 28, # 50 p. 6381-6384

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Citation Number: 37

Abstract

1 and biological 2 studies of the carbocyclic analogues of nucleosides.(-)-Aristeromycin and (-)-neplanocin A are natural representatives of these compounds. Yet, only a few enantiomerically pure synthetic carbocyclic nucleoside analogues have been obtained through chemoenzymatic 3 approaches, 4 multistep synthesis, and by 5 chromatographic or enzymatic 6 resolution of racemic intermediates, nucleosides or nucleotides. The key ...