The Discovery of orally available thrombin inhibitors: Studies towards the optimisation of CGH1668

J Ambler, E Baker, L Brown, P Butler, D Farr…

Index: Bioorganic and Medicinal Chemistry Letters, , vol. 8, # 24 p. 3583 - 3588

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Citation Number: 12

Abstract

... Bioorganic & Medicinal Chemistry Letters. ... The chemical optimisation of CGH1668 1 is described employing an in vivo model of absorption to determine the influence on bioavailability of single point modifications to five key molecular templates. ...