γ-Carboline derivatives with anti-bovine viral diarrhea virus (BVDV) activity

K Sako, H Aoyama, S Sato, Y Hashimoto…

Index: Sako, Kumiko; Aoyama, Hiroshi; Sato, Shinichi; Hashimoto, Yuichi; Baba, Masanori Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 7 p. 3780 - 3790

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Citation Number: 47

Abstract

Based on anti-viral screening of our heteroaromatics derived from thalidomide, the γ- carboline skeleton has been identified as a superior scaffold structure for compounds with potent anti-bovine viral diarrhea virus (BVDV) activity. Structural development studies led to a potent anti-viral agent, SK5M (5-methyl-γ-carboline), with the EC50 of 0.26 μM.