A Convenient Method for C-Azanucleosides Synthesis

…, T Akiba, Y Ochiai, A Momotake, H Togo

Index: Yokoyama, Masataka; Akiba, Takahiro; Ochiai, Yoshie; Momotake, Atsuya; Togo, Hideo Journal of Organic Chemistry, 1996 , vol. 61, # 17 p. 6079 - 6082

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Citation Number: 25

Abstract

As a part of our program for synthesis and evaluation of the C-nucleosides as a new type of DNA unit, 1 we have been interested in the C-azanucleosides in which the endocyclic ribosyl ring oxygen is replaced with a nitrogen atom. To our knowledge, many modified nojirimycins, which function as effective glycosidase inhibitors, have been reported, 2 and only three C-azanucleosides3 have been synthesized as nojirimycin analogs. However, ...