Ring-substituted imidazoles as a new class of anti-tuberculosis agents

P Gupta, S Hameed, R Jain

Index: Gupta, Preeti; Hameed, Shahul; Jain, Rahul European Journal of Medicinal Chemistry, 2004 , vol. 39, # 9 p. 805 - 814

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Citation Number: 83

Abstract

We describe in vitro anti-Mycobacterium tuberculosis activities of ring-substituted-1H- imidazole-4-carboxylic acid derivatives (1–6), and 3-(2-alkyl-1H-imidazol-4-yl)-propionic acid derivatives (7–13) against drug-sensitive and drug-resistant M. tuberculosis H37Rv strains. The most effective analogues, 2f (R= R1= c-C5H9), and 2h (R= R1= c-C6H11) have produced> 90% inhibition at a concentration of< 6.25 μg/ml in the drug-sensitive screen. ...