Design and Synthesis of Novel Cyclooxygenase??1 Inhibitors as Analgesics: 5??Amino??2??ethoxy??N??(substituted??phenyl) benzamides
…, K Motoshima, A Tai, F Yazama, H Kakuta
Index: Fukai, Ryosuke; Zheng, Xiaoxia; Motoshima, Kazunori; Tai, Akihiro; Yazama, Futoshi; Kakuta, Hiroki ChemMedChem, 2011 , vol. 6, # 3 p. 550 - 560
Full Text: HTML
Citation Number: 3
Abstract
Abstract We previously found that N-(4-aminophenyl)-4-trifluoromethylbenzamide (TFAP), a COX-1 inhibitor, exhibits an analgesic effect without causing gastric damage. Unfortunately, TFAP causes reddish purple coloration of urine, and its analgesic effect is less potent than that of indomethacin. Herein we describe our study focusing on the development of 4-and 5- amino-2-alkoxy-N-phenylbenzamide scaffolds, designed on the basis of the structures of ...
Related Articles:
Mizoroki–Heck Reactions with 4??Phenoldiazonium Salts
[Schmidt, Bernd; Hoelter, Frank; Berger, Rene; Jessel, Soenke Advanced Synthesis and Catalysis, 2010 , vol. 352, # 14-15 p. 2463 - 2473]
[Paulis, Tomas de; Janowsky, Aaron; Kessler, Robert M.; Clanton, Jeffrey A.; Smith, Howard E. Journal of Medicinal Chemistry, 1988 , vol. 31, # 10 p. 2027 - 2033]
[Morgentin, Remy; Pasquet, Georges; Boutron, Pascal; Jung, Frederic; Lamorlette, Maryannick; Maudet, Mickael; Ple, Patrick Tetrahedron, 2008 , vol. 64, # 12 p. 2772 - 2782]
[Journal of Medicinal Chemistry, , vol. 27, # 9 p. 1137 - 1141]