Inhibition of cytopathic effect of human immunodeficiency virus type-1 by various phorbol derivatives.

S El-Mekkawy, MR Meselhy, AAM Abdel-Hafez…

Index: El-Mekkawy, Sahar; Meselhy, Meselhy Ragab; Abdel-Hafez, Atef Abdel-Monem; Nakamura, Norio; Hattori, Masao; Kawahata, Takuya; Otake, Toru Chemical and Pharmaceutical Bulletin, 2002 , vol. 50, # 4 p. 523 - 529

Full Text: HTML

Citation Number: 11

Abstract

Forty-eight derivatives of phorbol (9) and isophorbol (14) were evaluated for their inhibition of human immunodeficiency virus (HIV)-1 induced cytopathic effects (CPE) on MT-4 cells, as well as their activation of protein kinase C (PKC), as indices of anti-HIV-1 and tumor promoting activities, respectively. Of these compounds, the most potent inhibition of CPE was observed in 12-O-tetradecanoylphorbol 13-acetate (8) and 12-O-acetylphorbol 13- ...