Synthesis of 3-substituted arylpyrazole-4-carboxylic acids

…, AB Lebedeva, VD Sheludyakov, EA Kovaleva…

Index: Lebedev; Lebedeva; Sheludyakov; Kovaleva; Ustinova; Kozhevnikov Russian Journal of General Chemistry, 2005 , vol. 75, # 5 p. 782 - 789

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Citation Number: 21

Abstract

Abstract A method was suggested for preparing previously unknown 3-aryl-substituted pyrazole-4-carboxylic acids, involving Vilsmeier formylation of semicarbazones of 26 available mono-and disubstituted acetophenones and 2-acetylthiophene followed by oxidation of the resulting 3-aryl-substituted pyrazole-4-carboxaldehydes under the action of potassium permanganate. The mechanism of the formylation reaction is discussed. The ...