Aromatic ring functionalization of benzolactam derivatives: New potent dopamine D 3 receptor ligands

…, H Hübner, P Gmeiner, CF Masaguer

Index: Ortega, Raquel; Huebner, Harald; Gmeiner, Peter; Masaguer, Christian F. Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 9 p. 2670 - 2674

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Citation Number: 10

Abstract

Since the discovery of the dopamine D3 receptor, an intensive effort has been directed toward the development of potent and selective ligands in order to elucidate the function and potential therapeutic advantages of targeting D3 receptors. As a part of our efforts, a novel series of substituted benzolactams derivatives was synthesized mostly through palladium- catalyzed reactions. Their affinities on D1–D4 receptors were evaluated and the data led ...