Conformational preferences in a benzodiazepine series of potent nonpeptide fibrinogen receptor antagonists

RM Keenan, JF Callahan, JM Samanen…

Index: Journal of Medicinal Chemistry, , vol. 42, # 4 p. 545 - 559

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Citation Number: 58

Abstract

... Journal of Medicinal Chemistry. ... Chemistry. The syntheses of the analogues in Table 1 are depicted in Scheme 1. The carboxylic acid 23 24a was subjected to Curtius rearrangement via conversion to the acyl azide to furnish the 8-amino derivative 24 in modest yield. ...