Palladium??Catalyzed Aryl Iodide Carbonylation as a Route to Imidazoline Synthesis: Design of a Five??Component Coupling Reaction

S Bontemps, JS Quesnel, K Worrall…

Index: Bontemps, Sebastien; Quesnel, Jeffrey S.; Worrall, Kraig; Arndtsen, Bruce A. Angewandte Chemie - International Edition, 2011 , vol. 50, # 38 p. 8948 - 8951

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Citation Number: 23

Abstract

Since Heck s initial discovery in 1974,[1] the palladiumcatalyzed carbonylation of aryl halides has emerged as an important approach to construct carbonyl-containing compounds.[2, 3] In contrast to the traditional use of carboxylic acids to form nucleophile– acyl bonds, which often require the conversion of the acid into a more reactive unit with harsh substrates (eg acid chlorides, using thionyl or oxalyl chloride), or the use of ...

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