Practical Methods for the Synthesis of Trifluoromethylated Alkynes: Oxidative Trifluoromethylation of Copper Acetylides and Alkynes
…, C Guissart, S Schweizer, Y Bouhoute…
Index: Tresse, Cedric; Guissart, Celine; Schweizer, Stephane; Bouhoute, Yassine; Chany, Anne-Caroline; Goddard, Mary-Lorene; Blanchard, Nicolas; Evano, Gwilherm Advanced Synthesis and Catalysis, 2014 , vol. 356, # 9 p. 2051 - 2060
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Citation Number: 17
Abstract
Abstract: Two practical and complementary methods are reported for the synthesis of trifluoromethylated alkynes. The first one, a mix-and-stir process, is based on the oxidative trifluoromethylation of readily available and bench-stable copper acetylides while the second one, which displays a broad substrate scope and has several advantages over existing procedures, is based on the oxidative copper-catalyzed direct trifluoromethylation ...
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