Evaluation of chelating agents as anti-angiogenic therapy through copper chelation

…, M Sproull, S Tantama, V Venditto, S Sankineni…

Index: Camphausen, Kevin; Sproull, Mary; Tantama, Steve; Venditto, Vincent; Sankineni, Sandeep; Scott, Tamalee; Brechbiel, Martin W. Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 19 p. 5133 - 5140

Full Text: HTML

Citation Number: 16

Abstract

The evaluation of several sets of polyamine donor chelating agents including a selection of novel hexadentate 1, 3, 5-cis, cis-triaminocyclohexane (tach) based derivatives were performed in an in vitro endothelial cell proliferation assay to assess their cytotoxicity and selectivity as novel anti-angiogenic agents. The selective nature of the anti-angiogenic agents for human umbilical vein endothelial cells (HUVEC) was compared to a normal ...

Related Articles:

Fused and bridged bi-and tri-cyclic lactams via sequential metallo-azomethine ylide cycloaddition–lactamisation

[Blaney, Paul; Grigg, Ronald; Rankovic, Zoran; Thornton-Pett, Mark; Xu, Juan Tetrahedron, 2002 , vol. 58, # 9 p. 1719 - 1737]

Studies on the total synthesis of bouvardin and deoxybouvardin: cyclic hexapeptide cyclization studies and preparation of key partial structures

[Journal of Organic Chemistry, , vol. 53, # 3 p. 487 - 499]

Studies on the total synthesis of bouvardin and deoxybouvardin: cyclic hexapeptide cyclization studies and preparation of key partial structures

[Journal of Organic Chemistry, , vol. 53, # 3 p. 487 - 499]

Camptothecin-20-PEG ester transport forms: the effect of spacer groups on antitumor activity

[Bioorganic and Medicinal Chemistry, , vol. 6, # 5 p. 551 - 562]

Verbesserte Synthese von tert.??Butyloxycarbonyl??aminosäuren durch pH??Stat??Reaktion

[Justus Liebigs Annalen der Chemie, , vol. 702, p. 188 - 196]

More Articles...