Synthesis of piperidine derivatives as potential analgetic agents

…, V Valenta, M Borovička, J Holubek…

Index: Jilek, Jiri; Rajsner, Miroslav; Valenta, Vladimir; Borovicka, Milos; Holubek, Jiri; et al. Collection of Czechoslovak Chemical Communications, 1990 , vol. 55, # 7 p. 1828 - 1853

Full Text: HTML

Citation Number: 3

Abstract

Abstract Reaction of N-(1-(2-phenylethyl)-4-piperidinyl) propionanilide (I) with phosphorus pentasulfide gave the thioamide VI. Acylation of N-(1-(2-phenylethyl)-4-piperidinyl) aniline with 2-(methoxy) acetic and 2-(methylthio) acetic anhydrides afforded the amides II and III. Treatment of 4-anilino-1-benzylpiperidine-4-methanol with thionyl chloride gave the spirocyclic sulfurous acid ester amide XIV. Reduction of the hydrochloride of ethyl 3-(1- ...