Synthesis and modeling studies with monocyclic analogues of mycophenolic acid
WK Anderson, TL Boehm, GM Makara…
Index: Anderson, Wayne K.; Boehm, Terri L.; Makara, Gergely M.; Swann, R. Thomas Journal of Medicinal Chemistry, 1996 , vol. 39, # 1 p. 46 - 55
Full Text: HTML
Citation Number: 37
Abstract
Two stepwise procedures, developed for the introduction of the (E)-4-methyl-4-hexenoic acid side chain of mycophenolic acid, were used in the synthesis of monocyclic mycophenolic acid analogues 2a-i. The derivatives with a methyl group or hydrogen at C-4 and lacking the lactone moiety were much less cytotoxic than mycophenolic acid. The monocyclic analogues with a C-4 chloro group did show some activity, albeit much less ...
Related Articles:
[Van Otterlo, Willem A. L.; Michael, Joseph P.; De Koning, Charles B. Synthetic Communications, 2007 , vol. 37, # 20 p. 3611 - 3621]
Manganese (III)-Mediated Formylation of Aromatic Compounds in the Presence of Malonic Acid
[Bulletin of the Chemical Society of Japan, , vol. 62, # 2 p. 545 - 550]
Manganese (III)-Mediated Formylation of Aromatic Compounds in the Presence of Malonic Acid
[Bulletin of the Chemical Society of Japan, , vol. 62, # 2 p. 545 - 550]
[Tetrahedron Letters, , vol. 51, # 23 p. 3041 - 3044]
[Tetrahedron Letters, , vol. 51, # 23 p. 3041 - 3044]