Repairing the Thiol??Ene Coupling Reaction

…, AT Tran, D Bonnaffé, J Habegger, Z Hu…

Index: Povie, Guillaume; Tran, Anh-Tuan; Bonnaffe, David; Habegger, Jacqueline; Hu, Zhaoyu; Le Narvor, Christine; Renaud, Philippe Angewandte Chemie - International Edition, 2014 , vol. 53, # 15 p. 3894 - 3898 Angew. Chem., 2014 , vol. 126, # 15 p. 3975 - 3979,5

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Citation Number: 20

Abstract

Abstract Thiol-ene coupling (TEC) reactions emerged as one of the most useful processes for coupling different molecular units under reaction mild conditions. However, TEC reactions involving weak C [BOND] H bonds (allylic and benzylic fragments) are difficult to run and often low yielding. Mechanistic studies demonstrate that hydrogen-atom transfer processes at allylic and benzylic positions are responsible for the lack of efficiency of the ...