Synthesis of Optically Active Methyl 7. BETA.-Hydroxykaurenoate with Potent Neuroprotective Activity

…, K Matsuura, M Yokota, M Kimura, M Yonaga…

Index: Toyota, Masahiro; Matsuura, Kiminori; Yokota, Masahiro; Kimura, Manami; Yonaga, Masahiro; Sugimoto, Hachiro; Ihara, Masataka Chemical and Pharmaceutical Bulletin, 2004 , vol. 52, # 9 p. 1153 - 1154

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Citation Number: 7

Abstract

(−)-Methyl 7β-hydroxykaurenoate (3) and its 4-demethyl acetate (−)-4 were both synthesized via methods that contained radical cyclization and intramolecular Diels-Alder reactions as key steps. Both compounds displayed potent neuroprotective activity against N-methyl-D- aspartate toxicity in cultured cortical neurons.