N-Urethane-protected amino alkyl isothiocyanates: synthesis, isolation, characterization, and application to the synthesis of thioureidopeptides

VV Sureshbabu, SA Naik, HP Hemantha…

Index: Sureshbabu, Vommina V.; Naik, Shankar A.; Hemantha; Narendra; Das, Ushati; Guru Row, Tayur N. Journal of Organic Chemistry, 2009 , vol. 74, # 15 p. 5260 - 5266

Full Text: HTML

Citation Number: 31

Abstract

Synthetically useful N-Fmoc amino-alkyl isothiocyanates have been described, starting from protected amino acids. These compounds have been synthesized in excellent yields by thiocarbonylation of the monoprotected 1, 2-diamines with CS2/TEA/p-TsCl, isolated as stable solids, and completely characterized. The procedure has been extended to the synthesis of amino alkyl isothiocyanates from Boc-and Z-protected amino acids as well. ...

Related Articles:

Inhibitors of acyl-CoA: cholesterol O-acyl transferase (ACAT) as hypocholesterolemic agents. 8. Incorporation of amide or amine functionalities into a series of …

[O'Brien; Sliskovic; Blankley; Roth; Wilson; Hamelehle; Krause; Stanfield Journal of Medicinal Chemistry, 1994 , vol. 37, # 12 p. 1810 - 1822]

Inhibitors of acyl-CoA: cholesterol O-acyl transferase (ACAT) as hypocholesterolemic agents. 8. Incorporation of amide or amine functionalities into a series of …

[O'Brien; Sliskovic; Blankley; Roth; Wilson; Hamelehle; Krause; Stanfield Journal of Medicinal Chemistry, 1994 , vol. 37, # 12 p. 1810 - 1822]

Inhibitors of acyl-CoA: cholesterol O-acyl transferase (ACAT) as hypocholesterolemic agents. 8. Incorporation of amide or amine functionalities into a series of …

[O'Brien; Sliskovic; Blankley; Roth; Wilson; Hamelehle; Krause; Stanfield Journal of Medicinal Chemistry, 1994 , vol. 37, # 12 p. 1810 - 1822]

Inhibitors of acyl-CoA: cholesterol O-acyl transferase (ACAT) as hypocholesterolemic agents. 8. Incorporation of amide or amine functionalities into a series of …

[O'Brien; Sliskovic; Blankley; Roth; Wilson; Hamelehle; Krause; Stanfield Journal of Medicinal Chemistry, 1994 , vol. 37, # 12 p. 1810 - 1822]

Synthesis of imidacloprid derivatives with a chiral alkylated imidazolidine ring and evaluation of their insecticidal activity and affinity to the nicotinic acetylcholine …

[Nishiwaki, Hisashi; Kuriyama, Mituhiro; Nagaoka, Hikaru; Kato, Akira; Yamauchi, Satoshi; Shuto, Yoshihiro; Akamatsu, Miki Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 21 p. 6305 - 6312,8]

More Articles...