Studies on Anti-MRSA Parenteral Cephalosporins. II. Synthesis and Antibacterial Activity of 7. BETA.-[2-(5-Amino-1, 2, 4-thiadiazol-3-yl)-2 (Z)-alkoxyiminoacetamido]-3 …

…, N Matsunaga, H Tawada, Y Iizawa, K Okonogi…

Index: Ishikawa; Kamiyama; Matsunaga; Tawada; Iizawa; Okonogi; Miyake Journal of Antibiotics, 2000 , vol. 53, # 10 p. 1071 - 1085

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Citation Number: 16

Abstract

In an effort to discover a novel cefozopran (CZOP) derivative having excellent antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA), we performed chemical modification of the alkoxyimino moiety and imidazo [1, 2-b] pyridazinium group of CZOP. Among the prepared compounds, the cyclopentyloxyimino derivative 7β-[2-(5-amino-1, 2, 4- thiadiazol-3-yl)-2 (Z)-cyclopentyloxyiminoacetamido]-3-(3, 6-diaminoimidazo [1, 2-b] ...