Reaction of 2??dimethylaminomethylene??1, 3??diones with dinucleophiles. I. Synthesis of 1, 5??disubstituted 4??acylpyrazoles

P Schenone, L Mosti, G Menozzi

Index: Schenone, Pietro; Mosti, Luisa; Menozzi, Giulia Journal of Heterocyclic Chemistry, 1982 , vol. 19, p. 1355 - 1361

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Citation Number: 81

Abstract

Abstract Reaction of open-chain and cyclic sym-1, 3-diones with N, N-dimethylformamide dimethyl acetal gave, generally in high yield, a series of sym-2-dimethylaminomethylene-1, 3-diones which reacted with phenylhydrazine and methylhydrazine to afford, generally in satisfactory yield, a number of 1, 5-disubstituted 4-acylpyrazoles. The applications and limits of this new pyrazole synthesis are presented and discussed.