Design, synthesis, and evaluation of novel heteroaromatic analogs of curcumin as anti-cancer agents

N Samaan, Q Zhong, J Fernandez, G Chen…

Index: Samaan, Nawras; Zhong, Qiu; Fernandez, Jayjoel; Chen, Guanglin; Hussain, Ali M.; Zheng, Shilong; Wang, Guangdi; Chen, Qiao-Hong European Journal of Medicinal Chemistry, 2014 , vol. 75, p. 123 - 131

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Citation Number: 21

Abstract

Abstract To improve the potential of curcumin to treat advanced hormone-refractory prostate cancer, three series (A–C) of heteroaromatic analogs (thirty two compounds) with different monoketone linkers have been synthesized and evaluated for cytotoxicity against two human androgen-independent prostate cancer cell lines (PC-3 and DU-145). Among them, thirty analogs are more potent than curcumin against PC-3 cells, and twenty one analogs ...