Organic letters

Cross-coupling of non-activated chloroalkanes with aryl Grignard reagents in the presence of iron/N-heterocyclic carbene catalysts

SK Ghorai, M Jin, T Hatakeyama, M Nakamura

Index: Ghorai, Sujit K.; Jin, Masayoshi; Hatakeyama, Takuji; Nakamura, Masaharu Organic Letters, 2012 , vol. 14, # 4 p. 1066 - 1069

Full Text: HTML

Citation Number: 56

Abstract

An efficient and high-yielding cross-coupling reaction of various primary, secondary, and tertiary alkyl chlorides with aryl Grignard reagents was achieved by using catalytic amounts of N-heterocyclic carbene ligands and iron salts. This reaction is a simple and efficient arylation method having applicability to a wide range of industrially abundant chloroalkanes, including polychloroalkanes, which are challenging substrates under conventional cross- ...

Related Articles:

Tetrakis (2-hydroxyphenyl) ethene and derivatives. A structurally preorganized tetradentate ligand system for polymetallic coordination chemistry and catalysis

[Verkerk, Udo; Fujita, Megumi; Dzwiniel, Trevor L.; McDonald, Robert; Stryker, Jeffrey M. Journal of the American Chemical Society, 2002 , vol. 124, # 34 p. 9988 - 9989]

Microwave-assisted methylation of phenols with DMF-DMA

[Belov, Pavel; Campanella, Veronica L.; Smith, Alison W.; Priefer, Ronny Tetrahedron Letters, 2011 , vol. 52, # 21 p. 2776 - 2779]

Non-catalytic conversion of C–F bonds of benzotrifluorides to C–C bonds using organoaluminium reagents

[Terao, Jun; Nakamura, Misaki; Kambe, Nobuaki Chemical Communications, 2009 , # 40 p. 6011 - 6013]

Carbon-Based Leaving Group in Substitution Reactions: Functionalization of sp3-Hybridized Quaternary and Tertiary Benzylic Carbon Centers

[Mahoney, Stuart J.; Lou, Tiantong; Bondarenko, Ganna; Fillion, Eric Organic Letters, 2012 , vol. 14, # 13 p. 3474 - 3477]

Silica gel as an effective catalyst for the alkylation of phenols and some heterocyclic aromatic compounds

[Journal of Organic Chemistry, , vol. 49, # 22 p. 4161 - 4165]

More Articles...