Amino acids and peptides. CIV. Synthesis of two analogues of deamino-oxytocin with a diminished ring not containing a disulphide bond

K Jošt, F Šorm

Index: Jost,K.; Sorm,F. Collection of Czechoslovak Chemical Communications, 1971 , vol. 36, p. 2795 - 2808

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Citation Number: 11

Abstract

Two analogues of deamino-oxytocin were synthesized in which the original 20-membered cyclic structure of the oxytocin molecule is replaced by a 19-membered ring. In one of these analogues, the disulphide bond is replaced by a single sulphur atom, in the other by a methylene group. Both analogues showed oxytocin-like activity, but far less than that of deamino-oxytocin.