Synthesis and resolution of 1, 1-bi-8-methylisoquinoline: Formation of an optically active complex with high chiral recognition

G Chelucci, MA Cabras, A Saba, A Sechi

Index: Chelucci, Giorgio; Cabras, M. Antonietta; Saba, Antonio; Sechi, Alessandra Tetrahedron Asymmetry, 1996 , vol. 7, # 4 p. 1027 - 1032

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Citation Number: 36

Abstract

The synthesis and resolution of 1, 1-bi-8-methylisoquinoline (±)-5 is reported. An optically active palladium complex with high chiral recognition was formed during the complexation between a chiral palladium complex and the two enantiomers of (±)-5. The free energy barrier ΔG≠ for interconversion of enantiomers was estimated to be 97, 2 KJ/mol at 40° C.