Synthesis and antispasmodic activity of lidocaine derivatives endowed with reduced local anesthetic action
JCS Costa, JS Neves, MVN de Souza…
Index: Bioorganic and Medicinal Chemistry Letters, , vol. 18, # 3 p. 1162 - 1166
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Citation Number: 13
Abstract
... Bioorganic & Medicinal Chemistry Letters. ... The present structure-activity relationship (SAR) study focused on chemical modifications of the structure of the local anesthetic lidocaine, and indicated analogues having reduced anesthetic potency, but with superior potency relative ...
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[Costa, Jorge C.S.; Neves, Josiane S.; de Souza, Marcus V.N.; Siqueira, Rodrigo A.; Romeiro, Nelilma C.; Boechat, Nubia; Silva, Patricia M.R.e; Martins, Marco A. Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 3 p. 1162 - 1166]