A Simple and Environmentally Benign Nitration of Pyrazoles by Impregnated Bismuth Nitrate
P Ravi, GM Gore, SP Tewari…
Index: Ravi; Gore, Girish M.; Tewari, Surya P.; Sikder, Arun K. Journal of Heterocyclic Chemistry, 2013 , vol. 50, # 6 p. 1322 - 1327
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Abstract
Abstract We report herein a facile, rapid, and environmentally friendly synthesis of nitropyrazoles in good yields using silica-bismuth nitrate and silica-sulfuric acid-bismuth nitrate at room temperature for the first time. The relatively non-toxic nature, ease of handling, easy availability, and low cost make the present procedure attractive for the nitration of a wide variety of diazoles in the drug and pharmaceutical industries.
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