Tetrahedron Letters

3-Alkoxy-4-bromothiophenes: general synthesis of monomers and regio-selective preparation of two dimers

G Savitha, N Hergué, E Guilmet, M Allain, P Frère

Index: Savitha, Gurunathan; Hergue, Noemie; Guilmet, Erwan; Allain, Magali; Frere, Pierre Tetrahedron Letters, 2011 , vol. 52, # 12 p. 1288 - 1291

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Citation Number: 4

Abstract

Cihaner and Onal reported the synthesis of 3-bromo-4-methoxythiophene in 70% yield by the reaction of methanolate anion on 3,4-dibromothiophene in the presence of CuO and KI. 12 However, this protocol suffers from various drawbacks. Firstly 3,4-dibromothiophene is an expensive starting material, which is synthesized in two steps from thiophene. 13 and 14 Secondly the procedure requires a long reaction time of about 3 days. We recently reported that the reaction time ...