Structure-cytoprotective activity relationship of simple molecules containing an α, β-unsaturated carbonyl system
AM Rodríguez, RD Enriz, LN Santagata…
Index: Rodriguez, Ana M.; Enriz, Ricardo D.; Santagata, Luis N.; Jauregui, Esteban A.; Pestchanker, Mauricio J.; Giordano, Oscar S. Journal of Medicinal Chemistry, 1997 , vol. 40, # 12 p. 1827 - 1834
Full Text: HTML
Citation Number: 25
Abstract
In previous reports we attributed the cytoprotective activity of several sesquiterpene lactones to the presence of a nonhindered electrophilic acceptor in their structure. We suggested that the mechanism of protection would be, at least in part, mediated through a reaction between the electrophilic acceptor and the sulfhydryl-containing groups of the mucosa. We report here the gastric cytoprotective effect of simple molecules containing an α, β-unsaturated ...
Related Articles:
Nuclear synthons: mesyltriflone as an olefin polyanion equivalent
[Hendrickson, James B.; Boudreaux, Gerald J.; Palumbo, Paul S. Journal of the American Chemical Society, 1986 , vol. 108, # 9 p. 2358 - 2366]
Cycloaddition of cyclopropanone acetals to tetracyanoethylene
[Wiering, P.G.; Steinberg, H. Journal of Organic Chemistry, 1981 , vol. 46, # 8 p. 1663 - 1666]
[Journal of the American Chemical Society, , vol. 111, # 15 p. 5824 - 5831]
Quantum chemical calculations on the Peterson olefination with α-silyl ester enolates
[Journal of Organic Chemistry, , vol. 67, # 21 p. 7378 - 7388]
[Journal of Organic Chemistry, , vol. 45, # 23 p. 4804 - 4805]