Total Synthesis of (−)??Lemonomycin

…, M Akaiwa, T Asakawa, Y Hamashima…

Index: Yoshida, Atsushi; Asakawa, Tomohiro; Hamashima, Yoshitaka; Kan, Toshiyuki; Akaiwa, Michinori; Yokoshima, Satoshi; Fukuyama, Tohru Chemistry--A European Journal, 2012 , vol. 18, # 36 p. 11192 - 11195,4

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Citation Number: 2

Abstract

(À)-Lemonomycin (1) belongs to a large family of tetrahydroisoquinoline (THIQ) alkaloids,[1] and was isolated from the fermentation broth of Streptomyces candidus (LLAP191) in 1964.[2] In 2000, researchers at Wyeth–Ayerst discovered that 1 shows antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus faecium (VREF),[3] as well as cytotoxicity to a human colon-tumor cell line ( ...