Isolation and Characterization of Process Related Substances of an Antipsychotic Drug: Iloperidone

…, CS Kuruva, VR Katla, NR Chamarthi

Index: Kilaru, Ravendra Babu; Kuruva, Chandra Sekhar; Katla, Venkata Ramana; Chamarthi, Naga Raju Asian Journal of Chemistry, 2013 , vol. 25, # 10 p. 5307 - 5310

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Abstract

Abstract Seven unknown recurring impurities were isolated during the synthesis of Iloperidone process. All six impurities were subsequently synthesized and characterized by FTIR, MS and NMR spectral data. The structures of impurities were confirmed as 1-[4-(3- chloropropoxy)-3-methoxyphenyl] ethanone (4), 1-[4-(3-hydroxypropoxy)-3-methoxy phenyl] ethanone (7), 1-[4-(3-bromopropoxy)-3-methoxyphenyl] ethanone (9), 1, 1'-[4, 4'-(propane- ...