Optimisation of two-photon induced cleavage of molecular linker systems for drug delivery
T Buckup, A Southan, HC Kim, N Hampp…
Index: Buckup; Southan; Kim; Hampp; Motzkus Journal of Photochemistry and Photobiology A: Chemistry, 2010 , vol. 210, # 2-3 p. 188 - 192
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Citation Number: 6
Abstract
Photoreactive linker systems for drug delivery in modern ophthalmology are crucial for the efficiency of such applications. We compare 5 different linker molecule candidates (truxillic acid and 4 dimers of coumarin derivates) in solution regarding their chemical stability and two-photon induced cleavage efficiency, and shed light into the role of molecular structure in the cleavage reaction. Dimers of the coumarin family showed much higher two-photon ...
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