Thiophene-core estrogen receptor ligands having superagonist activity
J Min, P Wang, S Srinivasan…
Index: Tung, Dang Thanh; Tuan, Dang Thanh; Rasool, Nasir; Villinger, Alexander; Reinke, Helmut; Fischer, Christine; Langer, Peter Advanced Synthesis and Catalysis, 2009 , vol. 351, # 10 p. 1595 - 1609
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Citation Number: 25
Abstract
... figure Scheme 2. Synthesis of 3,4-, 2,4-, 2,3-Substituted Thiophenes 4a–f, 6a–b, and 8a–b ... a Reagents and conditions: (a) [Pd] catalyst, Na 2 CO 3 , toluene/water (1:1), reflux, 24 h; (b ... To investigate the effect of a third substituent on the thiophene core, we synthesized a series of ...
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