The identification of pyrazolo [1, 5-a] pyridines as potent p38 kinase inhibitors

M Cheung, PA Harris, JG Badiang, GE Peckham…

Index: Cheung, Mui; Harris, Philip A.; Badiang, Jennifer G.; Peckham, Gregory E.; Chamberlain, Stanley D.; Alberti, Michael J.; Jung, David K.; Harris, Stephanie S.; Bramson, Neal H.; Epperly, Andrea H.; Stimpson, Stephen A.; Peel, Michael R. Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 20 p. 5428 - 5430

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Citation Number: 35

Abstract

Download PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... A series of pyrazolo[1,5-a]pyridine derivatives was designed and synthesized as novel potent p38 kinase inhibitors. Our approaches towards improving in vitro metabolism and in vivo pharmacokinetic properties of the series are described. ... A series of pyrazolo[1,5-a]pyridine derivatives ...