Inhibition of Aromatase (P450Arom) by some 1??(Benzofuran??2??ylmethyl) imidazoles

CP OWEN, PJ NICHOLLS, H SMITH…

Index: Owen; Nicholls; Smith; Whomsley The Journal of pharmacy and pharmacology, 1999 , vol. 51, # 4 p. 427 - 433

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Citation Number: 10

Abstract

Abstract Studies of a series of 1-(benzofuran-2-ylmethyl) imidazoles, 1–5, previously proposed as potential agents for prostatic cancer by their inhibition of 17β-hydroxylase: 17, 20-lyase (P450 17), have been extended to their selectivity against placental microsomal aromatase (P450 Arom) in man.

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