Tetrahedron Letters

Silica gel accelerated aza-Michael addition of amines to α, β-unsaturated amides

L You, S Feng, R An, X Wang, D Bai

Index: You, Lisha; Feng, Song; An, Rui; Wang, Xinhong; Bai, Donglu Tetrahedron Letters, 2008 , vol. 49, # 35 p. 5147 - 5149

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Citation Number: 31

Abstract

A novel method to synthesize β-amino amide has been developed via conjugated addition of amine to bulky α, β-unsaturated amides promoted by silica gel. The silica gel worked efficiently to accelerate the reaction and afforded the related adduct in good to excellent yield.