Journal of the American Chemical Society

5-and 7-Chloro-8-aminoquinoline1

CC Price, DB Guthrie

Index: Price; Guthrie Journal of the American Chemical Society, 1946 , vol. 68, p. 1592

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Citation Number: 7

Abstract

In the antimalarial drugs of the 4-dialkyl-aminoalkylarninoquinoline series, it has been reported that the presence of a group, especially a chlorine atom, in the 7-position gives drugs superior to those having a methoxyl group in the 0-position." This observation has suggested the preparation of the corresponding analog of pamaquine (l? lasniochin) with a 7-chlorine rather than a 6-methoxyl substituent. Unfortunately 7-chloro-8-arninoquinoline ...