N-trifluoroacetyl-β-alanine in the synthesis of carnosine

MS Cherevin, ZP Zubreichuk, LA Popova…

Index: Cherevin; Zubreichuk; Popova; Gulevich; Knizhnikov Russian Journal of General Chemistry, 2007 , vol. 77, # 9 p. 1576 - 1579

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Citation Number: 3

Abstract

Abstract Conditions have been developed for the synthesis of N-trifluoroacetyl-β-alanine, N- tifluoroacetyl-β-alanyl chloride, and N-trifluoroacetyl-β-alanine 4-nitrophenyl ester. These compounds reacted with histidine methyl ester or sodium salt to give N-trifluoroacetyl-β- alanyl-l-histidine methyl ester CF 3 CONHCH 2 CH 2· CONHCH (CH 2 C 3 H 3 N 2) COOCH 3 and N-trifluoroacetyl-β-alanyl-l-histidine CF 3 CONHCH 2 CH 2 CONHCH·(CH 2 C 3 H 3 ...