Synthesis and selective class III antiarrhythmic activity of novel N-heteroaralkyl-substituted 1-(aryloxy)-2-propanolamine and related propylamine derivatives

JA Butera, W Spinelli, V Anantharaman…

Index: Butera, John A.; Spinelli, Walter; Anantharaman, Viji; Marcopulos, Nicholas; Parsons, Roderick W.; et al. Journal of Medicinal Chemistry, 1991 , vol. 34, # 11 p. 3212 - 3228

Full Text: HTML

Citation Number: 34

Abstract

3 arrhythmias occur in patients suffering from coronary artery disease or from congestive heart failure. These patients constitute most of the population at risk for SCD and their long- term prophylactic treatment is the most challenging goal of antiarrhythmic the rap^.^^^ Cardiac arrhythmias result from abnormalities of either impulse generation, impulse conduction, or a combination of both! Several different mechanisms underlie each type of ...