Synthesis of novel strobilurin–pyrimidine derivatives and their antiproliferative activity against human cancer cell lines

B Chai, S Wang, W Yu, H Li, C Song, Y Xu, C Liu…

Index: Chai, Baoshan; Wang, Shuyang; Yu, Wenquan; Li, Huichao; Song, Chuanjun; Xu, Ying; Liu, Changling; Chang, Junbiao Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 12 p. 3505 - 3510

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Citation Number: 10

Abstract

A series of new strobilurin–pyrimidine analogs were designed and synthesized based on the structures of our previously discovered antiproliferative compounds I and II. Biological evaluation with two human cancer cell lines (A549 and HL60) showed that most of these compounds possessed moderate to potent antiproliferative activity. Two potent candidates (8f, IC50= 2.2 nM and 11d, IC50= 3.4 nM) were identified with nanomolar activity against ...