Parallel synthesis of novel antitumor agents: 1, 2, 3-triazoles bearing biologically active sulfonamide moiety and their 3D-QSAR

L Ou, S Han, W Ding, P Jia, B Yang…

Index: US4906756 A1, ;

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Citation Number: 6

Abstract

... Chemistry The synthesis of azides A1–A4 (Fig. 1) is outlined in Scheme 1. The N-sulfonation of l-alaninol (1a) or l-phenylalaninol (1b) to yield 2a–d was followed by the generation of the O-methylsulfonyls (3a–d), and finally az- idation with NaN3 to obtain 4a–d (A1–A4) [13,14]. ...